Hypoxia Signaling Pathways
Hypoxia, which refers to insufficient oxygen levels, is a significant stress factor that affects the behavior and function of cells. Our research focuses on understanding the signaling pathways that regulate cellular responses to hypoxia and how they are dysregulated in pathologic conditions. Specifically, we examine the HIF family of transcription factors, which are known to activate the expression of genes involved in hypoxic adaptation.
Extracellular vesicles for drug delivery and therapy
Exosomes are small extracellular vesicles that contain a unique collection of proteins, nucleic acids, lipids, and metabolites. Produced by virtually all cells in the body, they are believed to play a crucial role in regulating long-distance intercellular communication. Given their ability to selectively package and deliver molecules to specific cells, exosomes hold great potential as biological carriers for therapeutic agents. Our aim is to develop exosomes as a platform technology for regenerative therapy through strategic modifications of their structure and contents.